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Proteomics application to the study of rheumatoid arthritis and osteoarthritis

The study of both DNA and protein technologies has been marked by unprecedented achievement over the last decade. The completion of the Human Genome Project in 2001 is representative of a new era in genomics; likewise, proteomics research, which has revolutionized the way we study disease, offers the potential to unlock many of the pathophysiologic mechanisms underlying the clinical problems encountered by orthopaedic surgeons. These new fields are extending our approach to and investigation of the etiology and progression of musculoskeletal disorders, notably rheumatoid arthritis and osteoarthritis. Advances in proteomics technology may lead to the development of biomarkers for both rheumatoid arthritis and osteoarthritis. Such biomarkers would improve early detection of these diseases, measure response to treatment, and expand knowledge of disease pathogenesis.  Please review other articles and studies by Dr. Peter Millett on this website

 

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Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model

Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model: Particle-induced osteolysis is currently a major problem affecting the long-term survivorship of total joint replacements. Alendronate is a third-generation bisphosphonate that blocks osteoclastic bone resorption. The objective of this study was to determine whether alendronate could prevent particle-induced osteolysis or restore (reverse) bone loss in established osteolysis.  Please review other articles and studies by Dr. Peter Millett on this website.

 

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The effects of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro

The effects of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro: Particulate wear debris can induce the release of bone-resorbing cytokines from cultured macrophages and fibroblasts in vitro, and these mediators are believed to be the cause of the periprosthetic bone resorption which leads to aseptic loosening in vivo. Much less is known about the effects of particulate debris on the growth and metabolism of osteoblastic cells. Please review other articles and studies by Dr. Peter Millett on this website.

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