2023 ON/AGA Orthoregeneration Award Awarded to Steadman Philippon Research Institute and Dr. Peter Millett:
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“It is a thrill to have our original research recognized by the ON Foundation, an esteemed international organization that is dedicated to orthopaedic tissue regeneration,” said Dr. Millett.
“Not only do rotator cuff tears increase rapidly with age, but we also see an increased incidence of retears as patients get older. Hypothesizing that age-related cellular aging (senescence) may be a factor, we worked with a rotator cuff tear model, finding that animals receiving Fisetin and bone marrow stimulation had reduced creatine kinase in their blood, better muscle relaxation, less degeneration, as well as improved tissue markers and fewer senescent cells.”
Co-investigator Dr. Johnny Huard noted, “Surgeons and patients need safe, effective solutions for the pain and dysfunction that accompany rotator cuff repairs. This research opens the door for new thinking and better clinical solutions for our patients.”
“This novel work that resulted in a decrease in inflammatory properties and enhanced biomechanical functioning is extremely promising,” added Dr. Matthias Steinwachs, chief medical officer at SportClinic Zurich. “This is just the beginning of determining how such treatments might improve patients’ recovery.”
Dr. Millett shared, “For over 15 years SPRI has welcomed international visiting scholars—orthopaedic surgeons who work with us in our clinics and laboratories. The scholars not only bring ideas to Vail and help advance our research, but they also become ambassadors for SPRI when they return home. Dr. Rony Dey Hazra and his wife Dr. Maria Dey Hazra of Germany were our visiting scholars in 2021-2022 and contributed significantly to this research. This was absolutely a team effort and team win.”
This research was supported by a generous philanthropic contribution from Björn and Kathy Borgen of Vail, Colorado.
The original news article can be found here: Globe Newswire
