Proteomics: Applications to the Study of Rheumatoid Arthritis and Osteoarthritis

Authors:

Reuben Gobezie, Peter J Millett, David S Sarracino, Christopher Evans, Thomas S Thornhill

Abstract:

Rheumatoid arthritis (RA) and osteoarthritis (OA) are two of the most common chronic musculoskeletal disorders worldwide. A survey conducted by the American Academy of Orthopaedic Surgeons reported that 7.3 million orthopaedic procedures were performed in US hospitals in 1995. Of these, OA and back pain were the most commonly treated problems. Musculoskeletal disorders as a whole account for $215 billion each year in health care costs and loss of economic productivity.

Less common than OA, RA affects 1% of the population world- wide. Although the long-term prognosis for RA likely will improve with new pharmacologic therapies, the disease remains a difficult problem. Average life expectancy of afected patients is reduced by 3 to 18 years, and 80% of patients are disabled after 20 years. On average, the annual cost of each case of RA in the United States is approximately $6,000. Although contemporary drugs are effective, our ability to diagnose RA with a high degree of sensitivity and specificity remains limited. The development of a diagnostic assay—the identification of a biomarker for RA—would enable the delivery of new effective therapies earlier in the disease stage, possibly before signs of joint destruction manifest. Despite the many advances in our understanding of the pathophysiology of both RA and OA, identifying the etiology of these disorders continues to be elusive.

For the complete study: Proteomics: Applications to the Study of Rheumatoid Arthritis and Osteoarthritis

Peter Millett, MD

Average rating:

39 reviews

Alexandra Thompson

Mar 23, 2024

by Alexandra Thompson on Peter Millett, MD

110%

Dr. Millett and his team did a SLAP tear repair and bicep tenodesis on my left shoulder. I use my arms as an artist, and love to swim in the ocean, surf, paddle, and telemark ski. So regaining full use of my shoulder and keeping my bicep attached was very important to me. Now, over two years later, my shoulder has the equivalent range of motion as my other arm and as before the injury, and no pain. After the first three months it felt so good and was so strong that - to my horror - I completely forgot my six-month follow-up.

Not only did Dr. Millett and his team make my arm as good as new, but having had the experience of such kindness and expertise throughout the process of surgery and recovery is like an added shoulder superpower.

Thank you Rita, Brooke, Jason, Sarah, Camille, Olivia, Dr. Millett and everyone! And see you soon when my husband comes in for his knee...

Jeff Chandler

Jan 31, 2022

by Jeff Chandler on Peter Millett, MD

Flawless procedure, Easy recovery

Dr. Millet's repaired my knee and tibia, following a botched operation by a different surgeon. That procedure was virtually pain free and I was weight bearing within a few days. That was 18 years ago and the knee is still strong. A few years after the knee incident, Dr Millet repaired my shoulder. My insurance company approved me for 3 months of disability following that surgery. I was off pain medication in 2 days and had 90% range of motion within a week. I withdrew my disability claim and returned to work within two weeks of surgery. I’m not a famous athlete—just a regular guy. Nonetheless, I was treated like an NFL at the Steadman clinic. Most notable was the time for recovery. Other surgeons perform their hour-long task in the OR and don’t involve themselves in the other functions. Peter and his team manages the entire process from diagnosis, anesthesia, nursing care, and therapy. He takes a holistic approach to patient care and doesn’t skip any steps.

Jenn West

Jul 2, 2021

by Jenn West on Peter Millett, MD

Saved My Life

I went to Dr. Millett after 7 knee surgeries (6 on my right and 1 on my left) and had seen 11 different surgeons who all refused to remove femur metal from my right leg. I am highly allergic to metal and the chronic pain was leaving me bedridden for 3.5wks out of a month. He personally wrote me back on my inquiry, listened to my concerns, scheduled my surgery within a week (due to insurance issues) and personally followed up with my recovery. The level of patient care from Dr. Millett and his ENTIRE team is above any care I have ever received in my 20 years of dealing with orthopedic surgeons. There are not enough words to describe the level of care, dedication and professionalism you receive from Dr. Millett and his staff.
My only disappointment is that I did not find him sooner!!!

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Proteomics: Applications to the Study of Rheumatoid Arthritis and Osteoarthritis

Authors:

Abstract:

About the Author: Peter Millett, MD