Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model

Authors:

Peter J Millett, Matthew J Allen, Mathias P G Bostrom

Abstract:

Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model: Particle-induced osteolysis is currently a major problem affecting the long-term survivorship of total joint replacements. Alendronate is a third-generation bisphosphonate that blocks osteoclastic bone resorption. The objective of this study was to determine whether alendronate could prevent particle-induced osteolysis or restore (reverse) bone loss in established osteolys

For the complete study: Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model

About the Author: Peter Millett, MD

Pennsylvania native Peter J. Millett, M.D., M.Sc. is an internationally renowned sports orthopedic surgeon, researcher, and author with numerous patents for groundbreaking orthopedic and biologic innovations. As a partner at The Steadman Clinic, Dr. Millett has been consistently selected as one of the “Best Doctors in America” and has been ranked in the top 1% of Orthopaedic Surgeons by U.S. News and World Reports. Using advanced open and arthroscopic surgical techniques Dr. Millett focuses on restoring damaged joints, ligaments and bones in the shoulder, elbow and knee.

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