Authors:

Peter J Millett, Matthew J Allen, Mathias P G Bostrom

Abstract:

Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model: Particle-induced osteolysis is currently a major problem affecting the long-term survivorship of total joint replacements. Alendronate is a third-generation bisphosphonate that blocks osteoclastic bone resorption. The objective of this study was to determine whether alendronate could prevent particle-induced osteolysis or restore (reverse) bone loss in established osteolys

For the complete study: Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model