The goal of rotator cuff repair is to restore function, improve pain, and to achieve healing of the involved tendons. Significant improvements in the biomechanics of rotator cuff repair constructs have been made over the past decade . However, reported retear rates following rotator cuff repair have remained high. Therefore attention has turned to ways in which the healing environment can be enhanced to promote healing of the rotator cuff tendons back to the bone. Specifically, biologically active materials have been designed to enhance the strength and quality of the repaired tissue at the tendon footprint. Many biologic factors contribute to the coordination and implementation of the healing response. In an attempt to augment healing after surgery, many investigators have studied how to enhance physiologic healing. These include addition of growth factors and cells to the repair site as well as the use of suture materials and different surgical repair techniques. The purpose of this paper is to highlight the role of platelet rich plasma (PRP) and other biologic agents used to enhance healing in rotator cuff repair.