Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model

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Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model: Particle-induced osteolysis is currently a major problem affecting the long-term survivorship of total joint replacements. Alendronate is a third-generation bisphosphonate that blocks osteoclastic bone resorption. The objective of this study was to determine whether alendronate could prevent particle-induced osteolysis or restore (reverse) bone loss in established osteolys

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